Peer-reviewed Scientific Papers

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1. A. Puglisi, N. Bognanni, G. Vecchio, E. Bayir, P. van Oostrum, D. Shepherd, F. Platt and E. Reimhult, Grafting of Cyclodextrin to Theranostic Nanoparticles Im-proves Blood-Brain Barrier Model Crossing, Biomolecules (2023)

2. A. Puglisi, S. Bassini, E. Reimhult, "Cyclodextrin-Appended Superparamagnetic Iron Oxide Nanoparticles as Cholesterol-Mopping Agents" Frontiers in Chemistry (2021)

3. Bener, Semira, Antonino Puglisi, and Yusuf Yagci. "pH‐Responsive Micelle‐Forming Amphiphilic Triblock Copolymers." Macromolecular Chemistry and Physics (2020): 2000109.

4. A. Puglisi, E. Bayir, S. Timur, Y. Yagci, pH-Responsive Polymersome Microparticles as Smart Cyclodextrin-Releasing Agents, Biomacromolecules 2019, 20, 4001−4007. Gold Open Access

5. A. Puglisi,  Y. Yagci, Cyclodextrin-based macromolecular systems as cholesterol-mopping therapeutic agents in Niemann-Pick Disease Type C, Macromolecular Rapid Communications 2019, 40, 1800557- FREE ACCESS from MRC website throughout 2019- Green Open Access Highlighted in Advanced Science News

6. A. Puglisi, E. Murtezi, G. Yilmaz, Y. Yagci, Synthesis of Block Copolymers by Mechanistic Transformation from Photoinitiated Cationic Polymerization to RAFT Process, Polymer Chemistry, 2017, 8, 7307 - 7310

7. V.Oliveri, F.Attanasio, A.Puglisi, J.Spencer, G.Vecchio, Multifunctional 8-hydroxyquinoline-appended cyclodextrins as new inhibitors of metal-induced protein aggregation, Chemistry - A European Journal 2014, 20, 8954-8964 (back cover). Highlighted on the ChemistryViews website 

8. V.Oliveri, A.Puglisi, M.Viale, C.Aiello, C.Sgarlata, G.Vecchio, J.Clarke,J.Milton, J.Spencer, New Cyclodextrin-Bearing 8-Hydroxyquinoline Ligands as Multifunctional Molecules, Chemistry - A European Journal, 2013, 19, 13946 – 13955

9. J.Amin, A.Puglisi, J.Clarke, J.Milton, M.Wang, R.M.Paranal, J.E.Bradner, J.Spencer, A Cyclodextrin-Capped Histone Deacetylase Inhibitor, Bioorganic & Medicinal Chemistry Letters, 2013, 23(11), 3346–3348

10. A.Puglisi, J.Spencer, V.Oliveri, G.Vecchio, Xiaole Kong, J.Clarke, J.Milton, Synthesis, Physicochemical Properties and Antioxidant Activity of Deferiprone-Cyclodextrin Conjugates and their Iron (III) Complexes, Dalton Transactions, 2012, 41 (10), 2877 – 2883 (Front Cover)

11. A.Puglisi, J.Spencer, J.Clarke, J.Milton, Microwave-assisted synthesis of 6-amino-β-cyclodextrins, J. Incl. Phenom. Macrocyclic Chem., 2012, 73 (1-4), 475-478

12. V.Oliveri, A.Puglisi, G.Vecchio, New conjugates of β-cyclodextrin with manganese(III) salophen and porphyrin complexes as antioxidant systems, Dalton Transactions, 2011, 40, 2913-2919

13. A. Puglisi, E. Rizzarelli, G. Vecchio, R. Iacovino, E. Benedetti, C. Pedone, M. Saviano, Crystal and molecular structure of cyclodextrins functionalised with the anti-inflammatory drug etodolac, Biopolymers, 2009, 91 (12), 1227-1235

14. Contino, V. Cucinotta, A. Giuffrida, G. Maccarrone, M. Messina, A. Puglisi, G. Vecchio  , Synthesis and characterisation of the 3-amino-derivative of gamma-cyclodextrin, showing receptor ability and metal ion coordination properties, Tetrahedron Letters, 2008, 49, 4765-4767.

15. V. Cucinotta, A. Giuffrida, G. Maccarrone, M. Messina, A. Puglisi, G. Vecchio, Synthesis and NMR characterisation of β-alanine-bridged hemispherodextrin:A very efficient chiral selector in EKC, Electrophoresis, 2007, 28 (15) 2580-2588

16. A. Puglisi, R.Purrello, E.Rizzarelli, S.Sortino,  G.Vecchio, Spectroscopic and self-association behavior of a porphyrin-beta-cyclodextrin conjugate, New Journal of Chemistry, 2007, 31, 1499-1506

17. V.Cucinotta, A.Giuffrida, G.Maccarrone, M.Messina, A.Puglisi, E.Rizzarelli, G.Vecchio, Coordination properties of 3-functionalized b-cyclodextrins. Thermodynamic stereoselectivity of copper(II) complexes of the A,B-diamino derivative and its exploitation in LECE, Dalton Transactions, 2005, 2731-2736.

18. V.Cucinotta, A.Giuffrida, G.Maccarrone, M.Messina, A.Puglisi, A.Torrisi, G.Vecchio, The 6-derivative of b-cyclodextrin with succinic acid: a new chiral selector for CD-EKC, J. Pharm.Biomed. Anal., 2005, 37, 1009-1014

19. A.Puglisi, G.Tabbì, G.Vecchio, Bioconjugate of cyclodextrins of manganese salen-type ligand with superoxide dismutate activity, J.Inorg.Biochem. 2004, 98, 969-976

20. V.Cucinotta, A.Giuffrida, D.La Mendola, G.Maccarrone, A.Puglisi, E.Rizzarelli, G.Vecchio, 3-amino derivative of b-cyclodextrin: thermodynamics of copper(II) complexes and exploitation of its enantioselectivity in the separation of amino acid racemates by ligand exchange capillary electophoresis, J.Chromatogr. B, 2004, 800, 127-133

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Patents

 

1. E. Rizzarelli, G. Vecchio, A. Puglisi, D. La Mendola

Preparation of cyclodextrins functionalized with etodolac as specific site release agents

Eur. Pat. Appl. (2007), EP1860110.

 

2. R. V. Bowen, C. G. Brown, Clive, M. Bruce, A. J. Heron, J. E. Wallace, J. White, J. H. Lloyd, A. Antoni Alves, D. Caprotti, L, Jayasinghe, L. McNeill, J. Miton, A Puglisi, S. Soeroes.

Method for controlling the movement of a polynucleotide through a transmembrane pore

WO/2015/110777 (30th July 2015)

 

Web Article

 

Inside the “Doughnut”: the Versatile Chemistry of Cyclodextrins

On-line Update in An Introduction to Medicinal Chemistry - Graham L. Patrick (5edition – Jan 2013):

http://fdslive.oup.com/www.oup.com/orc/resources/chemistry/patrick5e/student/artices/patrick5e_webarticle04.pdf